SEP-363856 hydrochloride

SEP-363856 盐酸盐

(7S)-4,7-dihydro-N-methyl-5H-thieno[2,3-c]pyran-7-methanamine hydrochloride | SEP-363856 HCl | 1-[(7S)-4,7-dihydro-5H-thieno[2,3-c]pyran-7-yl]-N-methylmethanamine hydrochloride | (S)-1-(5,7-Dihydro-4H-thieno(2,3-C)pyran-7-yl)-N-methylmethanamine hydrochlo

SEP-363856 hydrochloride

S650186-5mg

5mg

≥99%

2-8°C储存,干燥

冰袋运输

SEP-363856 hydrochloride (SEP-856 hydrochloride), an orally active and CNS active psychotropic agent with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects. SEP-363856 hydrochloride (SEP-856 hydrochloride) has the potential for the study of schizophrenia In Vitro SEP-856 (10 μM) shows >50% inhibition of specific binding at α 2A , α 2B , D 2 , 5-HT 1A , 5-HT 1B , 5-HT 1D , 5-HT 2A , 5-HT 2B , 5-HT 2C , and 5-HT 7 receptors. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo SEP-856 (0.3, 1 and 10 mg/kg, i.p.) is CNS active and exhibits a behavioral signature similar to known antipsychotic drugs . SEP-856 (0.3, 1 and 10 mg/kg, orally once) significantly reduces PCP-induced hyperactivity . Oral SEP-856 administration (1, 3 and 10 mg/kg) produces a dosedependent decrease in REM sleep, increase in latency to REM sleep and increase in cumulative wake (W) time . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Acute treatment with phencyclidine (PCP), which induces robust hyperactivity in rodents . Dosage: 0.3, 1 and 3 mg/kg. Administration: Orally once. Result: Resulted in a dose-dependent inhibition of PCP-induced hyperactivity responses in C57Bl/6J mice (1-way ANOVA F (5, 59) = 18.96, p Form:Solid IC50& Target:TAAR1 0.140 μM (EC 50 ) 5-HT 1A Receptor 2.3 μM (EC 50 ) 5-HT 1B Receptor 15.6 μM (EC 50 ) 5-HT 1D Receptor 0.262 μM (EC 50 ) 5-HT 2A Receptor >10 μM (EC 50 ) 5-HT 2C Receptor 30 μM (EC 50 ) 5-HT 7 Receptor 6.7 μM (EC 50 )

SEP-363856 hydrochloride（SEP-856 盐酸盐）是一种口服活性中枢神经系统活性精神药物，具有独特的非 D2/5-HT2A 作用机制，可发挥类似抗精神病药的作用。SEP-363856 盐酸盐（SEP-856 盐酸盐）具有以下功效

1310422-41-3

C9H14ClNOS

219.73 g/mol

833-503-6

139415154

CNC[C@H]1C2=C(CCO1)C=CS2.Cl

1-[(7S)-5,7-dihydro-4H-thieno[2,3-c]pyran-7-yl]-N-methylmethanamine;hydrochloride

1S/C9H13NOS.ClH/c1-10-6-8-9-7(2-4-11-8)3-5-12-9;/h3,5,8,10H,2,4,6H2,1H3;1H/t8-;/m0./s1

JRDQGVVFSHRVTL-QRPNPIFTSA-N

CNCC1C2=C(CCO1)C=CS2.Cl

139415154

1310422-41-3

H2O : 100 mg/mL (455.10 mM; Need ultrasonic) DMSO : 62.5 mg/mL (284.44 mM; Need ultrasonic)

2

3

2

219.048 Da

219.048 Da

49.500 Ų

13

0

153.000

0

2