SBI-425

小分子

SBI-425

S650219-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

SBI-425 is an orally active and potent TNAP ( tissue-nonspecific alkaline phosphatase ) inhibitor ( IC 50 =16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival In Vitro SBI-425 treatment suppresses Foxp3 expression in CD4 + and CD8 + T cells in splenocytes from CLP-injured mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo 1.19 Mouse PK parameters for SBI-425 Compds SBI-425 Cl p (mL/min/kg) 5.14 Vd (L/kg) 1.03 C max (μg/mL) 178 AUC (μg*hr/mL) 848 t 1/2 (hr) 2.3 %F 58 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 16 nM (TNAP)

SBI-425 是一种口服活性强效 TNAP（组织非特异性碱性磷酸酶）抑制剂（IC 50 =16 nM）。SBI-425 可抑制血管中的 TNAP，改善心血管参数和存活率。

1451272-71-1

C13H12ClN3O4S

341.77 g/mol

89768286

COC1=C(C=C(C=C1)Cl)S(=O)(=O)NC2=CN=CC(=C2)C(=O)N

5-[(5-chloro-2-methoxyphenyl)sulfonylamino]pyridine-3-carboxamide

1S/C13H12ClN3O4S/c1-21-11-3-2-9(14)5-12(11)22(19,20)17-10-4-8(13(15)18)6-16-7-10/h2-7,17H,1H3,(H2,15,18)

SBAITEDLNTYIOE-UHFFFAOYSA-N

COC1=C(C=C(C=C1)Cl)S(=O)(=O)NC2=CN=CC(=C2)C(=O)N

89768286

5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide;SBI-425

DMSO : 86.67 mg/mL (253.59 mM; Need ultrasonic)

2

6

5

341.024 Da

341.024 Da

120.000 Ų

22

0

496.000

0

1

0.900