SynuClean-D

SynuClean-D

S650895-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

SynuClean-D (SC-D) is an inhibitor of α-synuclein aggregation, disrupts mature amyloid fibrils, prevents fibril propagation, and abolishes the degeneration of dopaminergic neurons in an animal model of Parkinson’s disease. In Vitro SynuClean-D significantly reduces the in vitro aggregation of wild-type α-synuclein and the familiar A30P and H50Q variants in a substoichiometric molar ratio. SynuClean-D prevents fibril propagation in protein-misfolding cyclic amplification assays and decreases the number of α-synuclein inclusions in human neuroglioma cells. Computational analysis suggests that SynuClean-D can bind to cavities in mature α-synuclein fibrils and, indeed, it displays a strong fibril disaggregation activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo The treatment with SynuClean-D of two parkinson’s disease (PD) Caenorhabditis elegans models, expressing α-synuclein either in muscle or in dopaminergic neurons, significantly reduces the toxicity exerted by α-synuclein. SynuClean-D-treated worms show decreased α-synuclein aggregation in muscle and a concomitant motility recovery. More importantly, this compound is able to rescue dopaminergic neurons from α-synuclein-induced degeneration . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

SynuClean-D（SC-D）是一种α-突触核蛋白聚集抑制剂，能破坏成熟的淀粉样纤维，防止纤维扩展，并在帕金森病动物模型中消除多巴胺能神经元的退化。

685121-45-3

C13H5F3N4O5

354.20 g/mol

2726228

C1=CC(=CC(=C1)[N+](=O)[O-])C2=C(C(=C(C(=O)N2)C#N)C(F)(F)F)[N+](=O)[O-]

5-nitro-6-(3-nitrophenyl)-2-oxo-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile

1S/C13H5F3N4O5/c14-13(15,16)9-8(5-17)12(21)18-10(11(9)20(24)25)6-2-1-3-7(4-6)19(22)23/h1-4H,(H,18,21)

OJRLTEJFYMZKQB-UHFFFAOYSA-N

C1=CC(=CC(=C1)[N+](=O)[O-])C2=C(C(=C(C(=O)N2)C#N)C(F)(F)F)[N+](=O)[O-]

2726228

DMSO : 83.33 mg/mL (235.26 mM; Need ultrasonic)

1

9

1

354.021 Da

354.021 Da

145.000 Ų

25

0

750

0

1

1.6