SNT-207707

SNT-207707

S650988-5mg

5mg

≥99%

2-8°C储存,干燥

冰袋运输

SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC 50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor. In Vitro SNT-207707 binds to the MC-4 receptor with an affinity of 8 nM and shows a more than 200-fold selectivity vs. MC-3 and MC-5. SNT207858 is a 22 nM MC-4 antagonist with a 170-fold selectivity vs. MC-3 and a 40-fold selectivity versus MC-5. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Single subcutaneous injection of 20 mg/kg of SNT-207707 distinctly increases food intake of the mice. Once daily oral administration of both compounds SNT207858 and SNT-207707 starting the day after tumor implantation significantly reduces the tumor induced weight loss . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 8 nM (binding MC-4), 5 nM (function MC-4)

SNT-207707 是一种选择性、强效和口服活性的黑色素皮质素 MC-4 受体拮抗剂，对 MC-4 受体的 IC 50 为 8 nM（结合）和 5 nM（功能）。

1064662-40-3

C32H44ClN5O

550.18 g/mol

131843715

2-(4-cyanophenyl)-N,N-bis(3-methylbutyl)-3-(3-pyrrolidin-1-ylpropyl)imidazo[1,2-a]pyridine-6-carboxamide;hydrochloride

1S/C32H43N5O.ClH/c1-24(2)15-20-36(21-16-25(3)4)32(38)28-13-14-30-34-31(27-11-9-26(22-33)10-12-27)29(37(30)23-28)8-7-19-35-17-5-6-18-35;/h9-14,23-25H,5-8,15-21H2,1-4H3;1H

FBNJDWPWZNPVSC-UHFFFAOYSA-N

CC(C)CCN(CCC(C)C)C(=O)C1=CN2C(=NC(=C2CCCN3CCCC3)C4=CC=C(C=C4)C#N)C=C1.Cl

131843715

DMSO : ≥ 250 mg/mL (454.40 mM)

1

4

12

549.323 Da

549.323 Da

64.599 Ų

39

0

764.000

0

2