SIRT-IN-2

小分子

SIRT-IN-2

S651151-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

SIRT-IN-2 is a potent inhibitor of SIRT1/2/3 , with IC 50 s of 4, 4, 7 μM, respectively. In Vitro SIRT-IN-2 (compound 31) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC 50 values are 4, 4, 7 μM, respectively. SIRT-IN-2 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 Å), occupying the nicotinamide C-pocket and acetyl lysine substrate channel. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:SIRT1 4 μM (IC 50 ) SIRT2 1 μM (IC 50 ) SIRT3 7 μM (IC 50 )

SIRT-IN-2 是 SIRT1/2/3 的强效抑制剂，其 IC 50 s 分别为 4、4 和 7 μM。

1431411-66-3

C15H21N5O3S2

383.49 g/mol

71304815

CS(=O)(=O)NCCC1CCN(CC1)C2=NC=NC3=C2SC(=C3)C(=O)N

4-[4-[2-(methanesulfonamido)ethyl]piperidin-1-yl]thieno[3,2-d]pyrimidine-6-carboxamide

1S/C15H21N5O3S2/c1-25(22,23)19-5-2-10-3-6-20(7-4-10)15-13-11(17-9-18-15)8-12(24-13)14(16)21/h8-10,19H,2-7H2,1H3,(H2,16,21)

BKOWIHMCGFRARN-UHFFFAOYSA-N

CS(=O)(=O)NCCC1CCN(CC1)C2=NC=NC3=C2SC(=C3)C(=O)N

71304815

DMSO : 62.5 mg/mL (162.98 mM; Need ultrasonic)

2

8

6

383.109 Da

383.109 Da

155.000 Ų

25

0

574

0

1

1.2