SB 258719

小分子

3,N-Dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl)-propyl]-benzenesulfonamide (SB-258719) | SB-258,719 | SCHEMBL2471088 | 3-METHYL-N-[(1R)-1-METHYL-3-(4-METHYL-1-PIPERIDINYL)PROPYL]-N-METHYLBENZENESULFONAMIDE HYDROCHLORIDE | Benzenesulfonamide, N,3-dime

SB 258719

S651783-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

SB 258719 is a selective 5-HT 7 receptor antagonist with high affinity ( pK i =7.5) for the receptor. SB 258719 can be used for the research of cancer and neurological disease In Vitro SB 258719 (1, 3 and 10 μM; HEK 293 cells) produces a concentration-related rightward-shift of the 5-CT concentration-response curve with no signifcant alteration in the maximal response to 5-CT. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo SB 258719 (5-20 mg/kg; i.p.) significantly attenuates the 5-CT-induced hypothermia. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Swiss Webster mice (20-25 g). Dosage: 5-20 mg/kg Administration: I.p. Result: Significantly attenuated the 5-CT-induced hypothermia. Form:Liquid IC50& Target:5-HT 7 Receptor 7.5 (pKi)

SB 258719 是一种选择性 5-HT 7 受体拮抗剂，对该受体具有高亲和力（pK i =7.5）。SB 258719 可用于癌症和神经系统疾病的研究。

195199-95-2

C18H30N2O2S

338.51 g/mol

5312148

CC1CCN(CC1)CC[C@@H](C)N(C)S(=O)(=O)C2=CC=CC(=C2)C

N,3-dimethyl-N-[(2R)-4-(4-methylpiperidin-1-yl)butan-2-yl]benzenesulfonamide

1S/C18H30N2O2S/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18/h5-7,14-15,17H,8-13H2,1-4H3/t17-/m1/s1

AGVNHDNTFYHZNL-QGZVFWFLSA-N

CC1CCN(CC1)CCC(C)N(C)S(=O)(=O)C2=CC=CC(=C2)C

5312148

DMSO : 250 mg/mL (738.53 mM; Need ultrasonic)

0

4

6

338.203 Da

338.203 Da

49.000 Ų

23

0

452

0

1

3.5

NONHforallmodesoftransport