SLF

小分子

SLF

S655134-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC 50 of 2.6 μM for FKBP12. SLF can be used in the synthesis of PROTAC . In Vitro Three scout fragments-KB02, KB03, and KB05 are fused, which cover two different electrophile groups (chloroacetamide and acrylamide) and display broad cysteine reactivity in the human proteome-to the SLF ligand that binds tightly and selectively to FKBP12, a cytosolic prolyl isomerase that has been frequently used to study ligand-induced protein degradation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SLF 是一种 FK506 结合蛋白（FKBP）的合成配体，对 FKBP51 的亲和力为 3.1 μM，对 FKBP12 的 IC 50 为 2.6 μM。SLF 可用于合成 PROTAC。

195513-96-3(DMSO)

C30H40N2O6

524.65 g/mol

CCC(C)(C)C(=O)C(=O)N1CCCCC1C(=O)OC(CCC2=CC(=C(C=C2)OC)OC)C3=CC(=CC=C3)N