SGC-iMLLT

未知

同步加速器

SGC-iMLLT

S656347-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

SGC-iMLLT is a first-in-class chemical probe and a potent, selective inhibitor of MLLT1/3-histone interactions with an IC 50 of 0.26 μM. SGC-iMLLT shows high binding activity towards MLLT1 YEATS domain (YD) and MLLT3 YD (AF9/YEATS3) with K d s of 0.129 and 0.077 μM, respectively In Vivo SGC-iMLLT shows moderate metabolic resistance with t 1/2 of 53 min and 48 % remaining after 60 min, and the primary process for metabolism is N demethylation . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 0.26 μM (MLLT1 YD), Kd: 0.077 μM (MLLT3 YD), 0.129 μM (MLLT1 YD)

SGC-iMLLT 是一种首创的化学探针，也是 MLLT1/3 组蛋白相互作用的强效选择性抑制剂，其 IC 50 为 0.26 μM。SGC-iMLLT 对 MLLT1 YEATS 结构域（YD）和 MLLT3 YD（AF9/YEATS3）具有很高的结合活性，其 K d s 为 0.129 an (0.129μM)。

2255338-25-9(DMSO)

C22H24N6O

388.47 g/mol

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