SEL120-34A monohydrochloride

SEL120-34A 单盐酸盐

SEL120-34A monohydrochloride

S661572-1ml

1ml

10mM in DMSO

干燥,-80℃储存

超低温冰袋运输

SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC 50 s of 4.4 nM and 10.4 nM, respectively, with a K d of 3 nM for CDK8 . SEL120-34A monohydrochloride IC50& Target:CDK8/CycC 4.4 nM (IC 50 ) CDK19/CycC 10.4 nM (IC 50 ) CDK9/cycT 1070 nM (IC 50 ) In Vitro:SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC 50 s of 4.4 nM and 10.4 nM, respectively, with a K d of 3 nM for CDK8. SEL120-34A monohydrochloride w In Vivo:SEL120-34A monohydrochloride (30, 60mg/kg, p.o. once every day) inhibits growth of AML tumors in a dose-dependent manner in SCID mice after treatment for 17 days. MCE has not independently confirmed the accuracy of these methods. They are for refere Biological Activity:SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC 50 s of 4.4 nM and 10.4 nM, respectively, with a K d of 3 nM for CDK8 . SEL120-34A monohydrochloride

C15H19Br2ClN4

450.6 g/mol

CC1=C2C3=C(C(Br)=C1Br)CCCN3C(N4CCNCC4)=N2.Cl

包含CDK，MAPK，GSK3，CLK家族