SAG dihydrochloride

SAG 二盐酸盐

SAG dihydrochloride

S661659-1ml

1ml

10mM in DMSO

干燥,-80℃储存

超低温冰袋运输

SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist ( EC 50 =3 nM; K d =59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine ( HY-17024 ) inhibition of Smo . IC50& Target:EC50: 3 nM (Smo) In Vitro:SAG (0.1 nM-100 μM; 30 h) induces firefly luciferase expression in Shh-LIGHT2 cells with an EC 50 of 3 nM and then inhibits expression at higher concentrations. SAG (1-1000 nM; 1 h) competes for the binding of BODIPY-cyclopamine to Smo-expressing Cos In Vivo:SAG (1.0 mM) induces more osteogenesis mainly at the defect borders and a significant increase in BV/TV at the eight week timepoint in CD-1 mice. SAG (15-20mg/kg; i.p.) induces pre-axial polydactyly prevalently in a dose-dependent manner in mice. Biological Activity:SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist ( EC 50 =3 nM; K d =59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine ( HY-17024 ) inhibition of Smo.

C28H30Cl3N3OS

562.98 g/mol

O=C(C1=C(Cl)C2=CC=CC=C2S1)N([C@H]3CC[C@H](NC)CC3)CC4=CC=CC(C5=CC=NC=C5)=C4.[H]Cl.[H]Cl