α,α′-Dichloro-o-xylene reacts with elemental tellurium and NaI in 2-methoxyethanol to form 1,1-diiodo-3,4-benzo-1-telluracyclopentane.α,α′-Dichloro-o-xylene was used in solid-phase synthesis of large combinatorial variations of fundamental peptide unit. α,α′-Dichloro-o-xylene reacts with elemental tellurium and NaI in 2-methoxyethanol to form 1,1-diiodo-3,4-benzo-1-telluracyclopentane. α,α′-Dichloro-o-xylene was used in solid-phase synthesis of large combinatorial variations of fundamental peptide unit.