山高雷帕霉素钠盐是雷帕霉素的分解产物，可以用作抗真菌剂。山高雷帕霉素钠盐是雷帕霉素的开环构象。研究表明山高雷帕霉素钠盐不能渗透Caco-2细胞的顶膜。还已经观察到山se雷帕霉素钠盐可以在整个顶膜上分泌，这可以被P-gp抑制剂LY335979抑制。相反，雷帕霉素是细胞可渗透的并且可以作为CYP3A4 / P-gp底物。 seco Rapamycin Sodium Salt is a decomposition product of Rapamycin which can function as an antifungal agent. seco Rapamycin Sodium Salt is the open ring conformation of Rapamycin. Studies suggest that seco Rapamycin Sodium Salt is impermeable to the apical membrane in Caco-2 cells. It has also been observed that seco Rapamycin Sodium Salt can be secreted across the apical membrane, which can be inhibited by the P-gp inhibitor, LY335979. In contrast, Rapamycin is cell permeable and can functions as a CYP3A4/P-gp substrate.