外消旋依非替尼具有L型和T型钙通道蛋白抑制剂活性。R（-）异构体似乎对T型钙通道具有很高的选择性。S（+）异构体几乎相等地抑制表达的Ca（V）1.2，Ca（V）1.3和Ca（V）3.1通道电流。 Racemic efonidipine has both L-type and T-type calcium channel protein inhibitor activity. The R(?)-isomer appears to be very selective for T-type calcium channel. The S(+)-isomer inhibits the expressed Ca(V)1.2, Ca(V)1.3 and Ca(V)3.1 channel currents almost equally.