Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na + /H + exchange inhibitor. In Vitro There is no significant effects of the Na + /H + exchange inhibitor eniporide on cardiac performance and high energy phosphate content in healthy pig hearts subjected to ischemia/reperfusion induced by crystalloid cardioplegic arrest. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo In stage 1, the administration of 100 mg and 150 mg eniporide results in smaller infarct sizes, especially in the angioplasty group. In contrast, in stage 2 there is no difference in the enzymatic infarct size between the three groups. Overall there is no effect of eniporide on clinical outcome (death, cardiogenic shock, heart failure, life-threatening arrhythmias). However, there is a significant reduction of the incidence of heart failure in patients reperfused late (>4 h). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Sodium Channel