Minocycline 是一种能透过血脑屏障的半合成四环素类抗生素。Minocycline 是一种缺氧诱导因子 (HIF-1α) 抑制剂。Minocycline 具有抗癌(anti-cancer)，抗炎(anti-inflammatory) 和谷氨酸 (glutamate) 拮抗作用。Minocycline 降低谷氨酸神经传递，显示神经保护特性和抗抑郁作用。Minocycline 通过与细菌核糖体 30S 亚基结合，抑制细菌蛋白的合成，从而产生抑菌 (bacteriostatic) 作用 Minocycline is a semi-synthetic tetracycline antibiotic that crosses the blood-brain barrier. Minocycline is an inhibitor of hypoxia-inducing factor (HIF-1α). Minocycline has anti-cancer, anti-inflammatory and glutamate antagonism. Minocycline reduces glutamate neurotransmission, showing neuroprotective properties and antidepressant effects. Minocycline inhibits the synthesis of bacterial proteins by binding with the 30S subunit of bacterial ribosomes, thus producing bacteriostatic effect