MHP (Methyl caprooyl tyrosinate) 是一种鞘氨醇激酶 (SPHK1) 激活剂，可显著增加 CAMP mRNA 和蛋白水平。MHP (Methyl caprooyl tyrosinate) 可增强抗微生物防御能力和先天免疫力。 Information Defensamide (MHP) Defensamide (MHP) is an activator of sphingosine kinase (SPHK1) . It can modulate the innate epidermal immune response by potentiating SPHK1 activity and inducing cAMP production. Targets SPHK1 In vitro Treatment with MHP directly activates SPHK1 and increases cellular S1P content in normal cultured human keratinocytes. MHP also stimulates CAMP production and enhances epidermal antimicrobial defense via the recently identified S1P-dependent mechanism. Defensamide (MHP) treatment also activates NF-κB which is assessed by nuclear translocation of NF-κB.