ACBI1 is a potent and cooperative SMARCA2 , SMARCA4 and PBRM1 degrader with DC 50 s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity. ACBI1 induces apoptosis In Vitro ACBI1 (1-10000 nM； 3-7 days) shows anti-proliferative activity. ACBI1 (0.3 µM; 100 h) induces apoptosis in SK-MEL-5 cells. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase von Hippel-Lindau. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: MV-4-11, NCI-H1568 cells Concentration: 0-1000 nM Incubation Time: 3-7 days Result: Showed anti-proliferative activity with IC 50 of 29, 68 nM for MV-4-11, NCI-H1568 cells, respectively. Apoptosis AnalysisCell Line: SK-MEL-5 cells Concentration: 0.3 µM Incubation Time: 100 h Result: Induced apoptosis in SK-MEL-5 cells. Form:Solid IC50& Target:DC 50 : 6 nM (SMARCA2), 11 nM (SMARCA4), 32 nM (PBRM1)