Temsirolimus (CCI-779) 抑制mTOR激酶活性 IC50值为1.76 ± 0.15 μM。A potent inhibitor of FRAP (mTOR) kinase activity Temsirolimus (CCI-779) directly inhibits mTOR kinase activity with IC50 values of 1.76 ± 0.15 μM. A potent inhibitor of FRAP (mTOR) kinase activity application： Temsirolimus is used as a rapamycin derivative with anti-cancer activity that inhibits mTOR. Temsirolimus is an antiproliferative and antiangiogenic, the first-in-class mTOR inhibitor approved for the treatment of patients with advanced poor prognosis renal cell carcinoma.