（R）-Equol是一种非甾体雌激素，由人类肠道菌群代谢异黄酮类植物雌激素黄豆苷元产生。它是一种以两种对映体形式存在的手性分子。与（S）-雌马酚的雌激素受体选择性相反，（R）-雌马酚是一种较弱的ER激动剂，它与ERα和ERβ的K | i |值分别为27.4和15.4 nM。与ERβ相比，（R）-对映体在ERα处表现出更高的ER激动剂活性。 (R)-Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein by human intestinal microflora. It is a chiral molecule that exists in two enantiomeric forms. In contrast to the estrogen receptor selectivity of (S)-equol , (R)-equol is a weaker ER agonist that binds to ERα and ERβ with K|i|values of 27.4 and 15.4 nM, respectively. The (R)-enantiomer demonstrates higher ER agonist activity at ERα compared to ERβ.