Information Ac-FLTD-CMK is a specific inhibitor for inflammatory caspases . Ac-FLTD-CMK inhibits gasdermin D (GSDMD) cleavage by caspases-1, -4, -5, and -11 in vitro. Ac-FLTD-CMK is effective against caspases-1, caspases-4 and caspases-5 with IC50 of 46.7 nM, 1.49 μM and 329 nM, respectively. Targets caspases-1 (Cell-free assay); caspases-5 (Cell-free assay); caspases-4 (Cell-free assay) 46.7 nM; 329 nM; 1.49 μM In vitro A GSDMD-derived inhibitor, N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone (Ac-FLTD-CMK), inhibits GSDMD cleavage in vitro and suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes. In vivo Ac-FLTD-CMK inhibits pyroptosis and exerts neuroprotective effect in a mice model of traumatic brain injury. Cell Research(from reference) Cell lines：BMDM cells Concentrations：10 μM Incubation Time：30 mins