代谢酶/蛋白酶

小分子

DDBEP | 6-[2-(4,4-dimethyl-2,3-dihydro-1-benzothiopyran-6-yl)ethynyl]-3-pyridinecarboxylic acid | 6-((4,4-Dimethylthiochroman-6-yl)ethynyl)nicotinic acid | 6-[(4,4-dimethyl-3,4-dihydro-2H-1-benzothiopyran-6-yl)ethynyl]nicotinic acid | 85FDJ14553 | Z111789

Tazarotenic acid

T302268-100mg

100mg

≥98%(HPLC)

2-8°C储存

冰袋运输

white to light brown powder Biochemical/Physiological Effects： Tazarotene is transformed to tazarotenic acid with the help of esterases. Tazarotenic acid regulates the pathogenic aspects of psoriasis through normalizing abnormal keratinocyte differentiation. It possesses strong anti-hyperproliferative effects in skin and reduces inflammation. Tazarotenic acid, an active metabolite of tazarotene, is a potent and selective agonist of the retinoid receptor (RAR) that binds to RARα, RARβ, and RARγ. Tazarotenic acid relatively selective activates RARβ and RARγ. Tazarotenic acid is a first xenobiotic substrate of human retinoic acid hydroxylase CYP26A1 and CYP26B1.

118292-41-4

C19H17NO2S

323.41 g/mol

MFCD00872121

147525

CC1(CCSC2=C1C=C(C=C2)C#CC3=NC=C(C=C3)C(=O)O)C

6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylic acid

1S/C19H17NO2S/c1-19(2)9-10-23-17-8-4-13(11-16(17)19)3-6-15-7-5-14(12-20-15)18(21)22/h4-5,7-8,11-12H,9-10H2,1-2H3,(H,21,22)

IQIBKLWBVJPOQO-UHFFFAOYSA-N

CC1(CCSC2=C1C=C(C=C2)C#CC3=NC=C(C=C3)C(=O)O)C

147525

504757309

1

4

3

323.098 Da

323.098 Da

75.500 Ų

23

0

518.000

0

1

4.200

NONHforallmodesoftransport