Trastuzumab (anti-HER2), erb-b2 受体酪氨酸激酶 2 抗体

抗体

曲妥珠单抗 | HER2药靶抗体 | CD340药靶抗体 | ErbB2药靶抗体 | HER2抗体 | CD340抗体 | ErbB2抗体

8-Aminoguanosine, >=98% (HPLC) | SHO2CA1BRO | Guanosine, 8-amino- | SCHEMBL483333 | 2,8-diamino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-purin-6-one | PD183255 | NSC 90390 | NSC816045 | NSC-816045 | NSC-90390 | BDBM50227263

Liquid

T411999-100μg

100μg

无动物源

≥95%(SDS-PAGE&SEC-HPLC)

>95%

-80℃储存,避免反复冻融

超低温冰袋运输

短期储存2-8℃（1-2周）；长期储存-80℃（24个月）；收货后建议分装，避免反复冻融。

10mM PBS, pH6.0.

No

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)

CHO supernatant

人(Human)

人(Human), 小鼠(Mouse) | 人(Human),小鼠(Mouse)

ERBB2/HER2/CD340

180288-69-1

26.0 kDa (Light Chain) & 50.6 kDa (Heavy Chain), under reducing conditions; 188.5 kDa, under non-reducing conditions.

Unconjugated

Human IgG1

重组抗体

kappa

Protein A purified

Primary antibody

24725081

抑制剂

erb-b2 受体酪氨酸激酶 2 抗体

Whole IgG