TRULI

TRULI

T647262-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

TRULI (Lats-IN-1) is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. TRULI promotes Yap-dependent proliferation in postmitotic mammalian tissues. In Vitro The IC 50 for TRULI increases with the ATP concentration. TRULI (10 μM; 24 hours) interferes with the ability of Lats kinases to phosphorylate Yap, with an EC 50 of 510 nM. TRULI causes Yap-dependent proliferation of murine supporting cells in the inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids. TRULI fosters both the G1-S and G2-M checkpoint transitions and yields supporting cells capable of transdifferentiation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: MCF 10A cells Concentration: 10 μM Incubation Time: 24 hours Result: Decreased the phosphorylation of Yap at residue S127. Form:Solid

TRULI（Lats-IN-1）是一种强效的 Lats1 和 Lats2 激酶 ATP 竞争性抑制剂。TRULI 能促进有丝分裂后哺乳动物组织中依赖 Yap 的增殖。

1424635-83-5

C18H14N4OS

334.4 g/mol

71890885

C1=CC=C(C=C1)CN2C=CSC2=NC(=O)C3=CNC4=C3C=CC=N4

N-(3-benzyl-1,3-thiazol-2-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide

1S/C18H14N4OS/c23-17(15-11-20-16-14(15)7-4-8-19-16)21-18-22(9-10-24-18)12-13-5-2-1-3-6-13/h1-11H,12H2,(H,19,20)

VTXBMVZVPUSAJF-UHFFFAOYSA-N

C1=CC=C(C=C1)CN2C=CSC2=NC(=O)C3=CNC4=C3C=CC=N4

71890885

DMSO : 50 mg/mL (149.53 mM; Need ultrasonic)

1

3

3

334.089 Da

334.089 Da

86.700 Ų

24

0

529.000

0

1

3.000