TAK-615

小分子

TAK-615

T650935-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

TAK-615 is a negative allosteric modulator (NAM) of the LPA1 receptor for the research of pulmonary fibrosis. TAK-615 binds the LPA1 receptor with high affinity ( K d high affinity of 1.7 nM and K d low affinity of 14.5 nM) In Vitro TAK-615 specifically binds to membranes expressing the human LPA1 receptor with estimated Kd high affinity (KdHi) of 1.7±0.5 nM and K d low affinity (KdLo) of 14.5±12.1 nM. TAK-615 is only able to partially inhibit the LPA response (~ 40% at 10 µM with an IC 50 of 23±13 nM in β-arrestin assay; 60% at 10 µM, IC 50 of 91±30 nM in calcium mobilisation assay). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:LPA1 Receptor 1.7-14.5 nM (Kd)

TAK-615 是一种用于肺纤维化研究的 LPA1 受体负异位调节剂（NAM）。TAK-615 与 LPA1 受体的结合亲和力很高（K d 高亲和力为 1.7 nM，K d 低亲和力为 14.5 nM）。

1664335-55-0

C25H22FNO4

419.44 g/mol

90659729

C1CC1CN(CC2=CC=C(C=C2)C(=O)O)C(=O)C3=CC=C(C=C3)OC4=CC=CC=C4F

4-[[cyclopropylmethyl-[4-(2-fluorophenoxy)benzoyl]amino]methyl]benzoic acid

1S/C25H22FNO4/c26-22-3-1-2-4-23(22)31-21-13-11-19(12-14-21)24(28)27(15-17-5-6-17)16-18-7-9-20(10-8-18)25(29)30/h1-4,7-14,17H,5-6,15-16H2,(H,29,30)

LEZVXIZCJXKBJY-UHFFFAOYSA-N

C1CC1CN(CC2=CC=C(C=C2)C(=O)O)C(=O)C3=CC=C(C=C3)OC4=CC=CC=C4F

90659729

4-(((cyclopropylmethyl)(4-(2-fluorophenoxy)benzoyl)amino)methyl)benzoic acid;TAK-615

DMSO : 125 mg/mL (298.02 mM; Need ultrasonic)

1

5

8

419.153 Da

419.153 Da

66.800 Ų

31

0

609

0

1

4.8