Tubulin inhibitor 1

小分子

微管蛋白抑制剂 1

Tubulin inhibitor 1

T651978-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

Tubulin inhibitor 1 is a tubulin inhibitor, inhibits tubulin polymerization. Tubulin inhibitor 1 shows potent anti-tumor activity, casues cellular mitotic arrest in the G2/M phase, and induces cellular apoptosis In Vitro Tubulin inhibitor 1 (Compound 7a3) is a tubulin inhibitor, inhibits tubulin polymerization. Tubulin inhibitor 1 has potent anti-proliferative activity against SK-OV-3, MDA-MB-231, HeLa, A549, CT26 and MCF-7 cells, with IC 50 s of 16.7 ± 3.0, 31.4 ± 0.7, 32.8 ± 2.9, 67.0 ± 0.8, 58.0 ± 2.4 and 35.4 ± 5.6 nM, respectively. Tubulin inhibitor 1 (40, 80, and 160 nM, 48 hours) markedly causes cellular mitotic arrest in the G2/M phase, induces apoptosis in SK-OV-3 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: SK-OV-3 cells Concentration: 40, 80, and 160 nM Incubation Time: 48 h Result: Induced apoptosis in SK-OV-3 cells after treatment for 48 h. In Vivo Tubulin inhibitor 1 (50 mg/kg, i.p., every two days three times for 20-25 days) is well tolerated, significantly reduces tumour growth in Balb/c nude mice bearing SK-OV-3 cells . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Six-week-old Balb/c nude mice (18-20 g) beraring SK-OV-3 cells Dosage: 50 mg/kg Administration: I.P., every two days three times for 20-25 days Result: Significantly reduced tumour growth in Balb/c nude mice bearing SK-OV-3 cells, without obvious body weight loss. Form:Solid IC50& Target:Tubulin

微管蛋白抑制剂 1 是一种微管蛋白抑制剂，可抑制微管蛋白的聚合。微管蛋白抑制剂 1 具有很强的抗肿瘤活性，能使细胞有丝分裂停滞在 G2/M 期，并诱导细胞凋亡。

2237054-53-2

C21H24N2O4

368.43 g/mol

137319628

CCOC1=CC=C(C=C1)C2=CN(N=C2C3=CC(=C(C(=C3)OC)OC)OC)C

4-(4-ethoxyphenyl)-1-methyl-3-(3,4,5-trimethoxyphenyl)pyrazole

1S/C21H24N2O4/c1-6-27-16-9-7-14(8-10-16)17-13-23(2)22-20(17)15-11-18(24-3)21(26-5)19(12-15)25-4/h7-13H,6H2,1-5H3

YWYCRTNRTJCKHS-UHFFFAOYSA-N

CCOC1=CC=C(C=C1)C2=CN(N=C2C3=CC(=C(C(=C3)OC)OC)OC)C

137319628

DMSO : ≥ 125 mg/mL (339.28 mM)