Teplinovivint

特普利诺维文

Teplinovivint

T654583-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

Teplinovivint is a potent wnt/β-catenin signaling pathway inhibitor. Teplinovivint has anti-inflammatory activity and has the potential for tendinopathy research. In Vitro Teplinovivint (compound 175; 0.0003-10 μM) inhibits Wnt/p-catenin activity in human colorectal cancecell line (SW480) in a dose-dependent manner (EC 50 =152.9 nM). Teplinovivint inhibits SW480 cells (EC 50 =25 nM) and primary human mesenchymal stem cells (hMSCs; EC 50 =10.377 μM). Teplinovivint (5.8, 10.8, 21.7, 41.7, 83.3, 166.6, 333.3, 750 nM) induced the expression of SCXA, TenacinC and Tenomodulin, in a dose-dependent manner with an EC 50 between 139-189 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Teplinovivint (compound 175; 10 mg/ml; once daily for 21 days via topical application) causes amelioration of inflammation as well as tendon degeneration. Teplinovivint results in a decrease of aninflammatory plasma biomarker, KC/GRO in the Collagenase-induced Tendon Injury Model . Teplinovivint (1 mg/ml with 1% BA) has a T max of 1 hours in plasma . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Teplinovivint 是一种强效的 wnt/β-catenin 信号通路抑制剂。Teplinovivint 具有抗炎活性，有望用于肌腱病研究。

1428064-91-8(DMSO)

C25H26N6O2

442.51 g/mol

O=C(C1=NNC2=C1C=C(C3=CC(CN4CCCCC4)=CN=C3)C=C2)NC5=CC=C(OC)N=C5