TRULI

TRULI

T654951-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

TRULI (Lats-IN-1) is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. TRULI promotes Yap-dependent proliferation in postmitotic mammalian tissues. In Vitro The IC 50 for TRULI increases with the ATP concentration. TRULI (10 μM; 24 hours) interferes with the ability of Lats kinases to phosphorylate Yap, with an EC 50 of 510 nM. TRULI causes Yap-dependent proliferation of murine supporting cells in the inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids. TRULI fosters both the G1-S and G2-M checkpoint transitions and yields supporting cells capable of transdifferentiation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: MCF 10A cells Concentration: 10 μM Incubation Time: 24 hours Result: Decreased the phosphorylation of Yap at residue S127.

TRULI（Lats-IN-1）是一种强效的 Lats1 和 Lats2 激酶 ATP 竞争性抑制剂。TRULI 能促进有丝分裂后哺乳动物组织中依赖 Yap 的增殖。

1424635-83-5(DMSO)

C18H14N4OS

334.4 g/mol

C1=CC=C(C=C1)CN2C=CSC2=NC(=O)C3=CNC4=C3C=CC=N4