TBK1-IN-1

TBK1-IN-1

T659201-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

TBK1-IN-1 is a potent and selective TANK binding kinase 1 (TBK1) inhibitor with an IC 50 value of 22.4 nM. TBK1-IN-1 inhibits TBK1 downstream target genes cxcl10 and ifnβ expression. TBK1-IN-1 has anticancer activity. Appearance:Solid IC50& Target:TBK1 22.4 nM (IC 50 ) In Vitro:TBK1-IN-1 (compound 7l; 0.1 and 1 μM; 2 h) inhibitsTBK1 downstream target genes cxcl10 and ifnβ expression in THP1 and RAW264.7 cells induced by poly (I:C) and lipopolysaccharide, respectively. TBK1-IN-1 (1-100 μM; 72 h) has moderate antiproliferativ Biological Activity:TBK1-IN-1 is a potent and selective TANK binding kinase 1 (TBK1) inhibitor with an IC 50 value of 22.4 nM. TBK1-IN-1 inhibits TBK1 downstream target genes cxcl10 and ifnβ expression. TBK1-IN-1 has anticancer activity.

C27H35N7O2

489.61 g/mol

CC(N1CCN(CC1)CC2=CC=CC(NC3=NC=C4C=CN(C4=N3)CCCNC(C5CCC5)=O)=C2)=O