Taltobulin hydrochloride

盐酸他妥布林

Taltobulin hydrochloride

T661574-1ml

1ml

10mM in DMSO

干燥,-80℃储存

超低温冰袋运输

Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin hydrochloride inhibits the polyme IC50& Target:Traditional Cytotoxic Agents In Vitro:Taltobulin (HTI-286; 0.2-7.3 nM; 3 days) inhibits the growth of 18 tumor cell lines (leukemia, ovarian, NSCLC, breast, colon, and melanoma cell lines) with an average IC 50 of 2.5±2.1 nM and a median value of 1.7 nM. MCE has not independently confirm In Vivo:Taltobulin (HTI-286; 1.6mg/kg i.v.) inhibits the growth of human tumor xenografts (e.g., HCT-15, DLD-1, MX-1W, and KB-8-5) in athymic nu/nu female mice. Taltobulin (HTI-286; 3mg/kg; p.o. gavage) inhibits growth by 97.3 % and 82% in athymic nu/nu fe Biological Activity:Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin hydrochloride inhibits the polyme

C27H44ClN3O4

510.11 g/mol

CC(C)(C)[C@H](NC([C@H](C(C)(C1=CC=CC=C1)C)NC)=O)C(N([C@@H](C(C)C)/C=C(C(O)=O)\\C)C)=O.Cl[H]