TRAM-34已被证明是人类T淋巴细胞中克隆和天然IK1通道的抑制剂。这些K+通道与细胞的过度增殖有关。抑制IK1通道已被证明可以根据TRAM-34的浓度调节细胞增殖。机制研究表明，TRAM-34可能导致细胞在G0/G1期停止生长。TRAM-34是一种选择性强的中间电导Ca2+激活K+通道（IKCa1，KCa3.1）抑制剂，Kd为20 nM，对其他离子通道的选择性为200至1500倍，并且不会阻断细胞色素P450。 TRAM-34 has been shown to be an inhibitor of cloned and native IK1 channels in human T lymphocytes. These K+ channels have been implicated in over-proliferation of cells. Inhibition of IK1 channels has been demonstrated to modulate cell proliferation depending on the concentration of TRAM-34. Mechanistic studies have shown that TRAM-34 may cause a halt in cell growth at the G0/G1 phase.TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450.