MMPIP hydrochloride is an allosteric metabotropic glutamate receptor 7 ( mGluR7 ) selective antagonist ( K B values 24 -30 nM). MMPIP hydrochloride acts as a pharmacological tool for elucidating the roles of mGluR7 on central nervous system functions. MMPIP hydrochloride alleviates pain and normalizes affective and cognitive behavior in neuropathic mice In Vitro MMPIP inhibits L-(+)-2-amino-4-phosphonobutyric acid (L-AP4; 0.5 mM)-induced intracellular Ca 2+ mobilization in Chinese hamster ovary (CHO) cells coexpressing rat mGluR7 with G α15 (IC 50 =26 nM). In CHO cells expressing rat mGluR7, MMPIP inhibits L-AP4-induced inhibition of forskolin-stimulated cAMP accumulation (IC 50 220 nM). MMPIP also antagonizes L-AP4-induced inhibition of cAMP accumulation with an IC 50 of 610 nM in CHO-human mGluR7/G α15. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo MMPIP (10 mg/kg) attenuates the amplitude of the acoustic startle response and markedly enhances the prepulse-induced inhibition of the acoustic startle response (up to 137% of control). MMPIP (10 mg/kg) rescues the MK-801 (0.1 mg/kg)-induced cognitive impairments, by improving the choice accuracy. Zamifenacin exhibits short elimination half-lives (plasma 1.16 h, brain 1.75 h) following i.p. administration (10 mg/kg) in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:mGlu7