Information TP0463518 TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with Ki of 5.3 nM for human PHD2. TP0463518 inhibits human PHD1, human PHD3 and monkey PHD2 with IC50 of 18 nM, 63 nM and 22 nM, respectively. Targets hPHD2 (Cell-free assay); hPHD1 (Cell-free assay); monkey PHD2 (Cell-free assay); hPHD3 (Cell-free assay) 5.3 nM(Ki); 18 nM; 22 nM; 63 nM