Information Tianeptine Tianeptine (S-1574, JNJ-39823277, TPI-1062) is an antidepressant agent that act as an atypical agonist of the μ-opioid receptor with clinically negligible effects on the δ- and κ-opioid receptors. Targets 5-HT ; μ-opioid receptor (for human μ-opioid receptor) ; 383 nM(Ki) In vitro Tianeptine modulates glutamatergic transmission. It restores stress-induced reduction of dendritic arborization in hippocampal neurons and reverses stress-induced inhibition of long-term potentiation at excitatory synapses in the hippocampus and prefrontal cortex. Tianeptine is a serotonin reuptake enhancer and has an antidepressant efficacy. In vivo In preclinical studies, tianeptine has beneficial effects in a number of behavioral models related to depression, anxiety and other stress-related disorders.