HBF-0259 is a potent and selective inhibitor of hepatitis B virus (HBV) surface antigen (HBsAg) secretion, with an EC 50 of 1.5 μM in HepG2.2.15 cells. HBF-0259 has no effect on HBV DNA synthesis. In Vitro HBF-0259 (0.0158-50.0 μM) inhibits the HBsAg secretion (EC 50 =1.5 μM) in HepDE19 cells, with an CC 50 of >50 μM. HBF-0259 (2-8 μM) significantly reduces the abundance of both L and M in the supernatants of HepG2.2.15 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid