c-Myc Max相互作用抑制剂。c-Myc癌蛋白及其伴侣Max是本质上无序的（ID）单体，它们在异二聚作用后会发生折叠和结合。与10058-F4类似，10074-G5通过与c-Myc结合来特异性抑制这种相互作用，从而阻止C-Myc特异性DNA结合和靶基因调控。10074-G5（2.8 microM）比10058-F4（5.2 microM）更有力，这是由于10074-G5与10054-F4结合的C-Myc区域不同。因此，对于探测不同的相互作用，该化合物可能变得合乎需要。 A c-Myc Max interaction inhibitor. The c-Myc oncoprotein and its partner Max are intrinsically disordered (ID) monomers that undergo coupled folding and binding upon heterodimerization. 10074-G5, similarly to 10058-F4, specifically inhibits this interaction by binding to c-Myc, thus preventing C-Myc specific DNA binding and target genes regulation. 10074-G5 (2.8 microM) is slightly more potent that 10058-F4 (5.2 microM) most likely due to the fact that 10074-G5 binds to a different region of C-Myc than 10054-F4. Thus, the compound may become desirable for probing different interactions.