说明： GSK2981278是强效的RORγ反向激动剂。 Information GSK2981278 GSK2981278 is a highly potent and selective inverse agonist for RORγ . Targets RORγ In vitro GSK2981278 has no significant effect on RORα-dependent activation. GSK2981278 significantly inhibits production of the Th17 signature (IL-17A, IL-17F, IL-22 and IL-23) in multiple in vitro and human tissue-based assays. In vivo GSK2981278 attenuates inflammation in a mouse model of psoriasis. Topical treatment with GSK2981278 will significantly limit Th17-type cytokine expression and should therefore lead to improved clinical outcomes for patients.