UK-371804

小分子

英国-371804

UK-371804

U650696-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

UK-371804 is a urokinase-type plasminogen activator ( uPA ) inhibitor with a K i of 10 nM. In Vitro UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC 50 =0.89 μM). UK-371804 has its excellent enzyme potency (K i =10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ki: 10 nM (uPA)

UK-371804 是一种尿激酶型纤溶酶原激活剂（uPA）抑制剂，K i 为 10 nM。

256477-09-5

C14H16ClN5O4S

385.83 g/mol

9952109

CC(C)(C(=O)O)NS(=O)(=O)C1=CC2=C(C=C1)C(=CN=C2N=C(N)N)Cl

2-[[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylamino]-2-methylpropanoic acid

1S/C14H16ClN5O4S/c1-14(2,12(21)22)20-25(23,24)7-3-4-8-9(5-7)11(19-13(16)17)18-6-10(8)15/h3-6,20H,1-2H3,(H,21,22)(H4,16,17,18,19)

XSDAXWRCPTYNOD-UHFFFAOYSA-N

CC(C)(C(=O)O)NS(=O)(=O)C1=CC2=C(C=C1)C(=CN=C2N=C(N)N)Cl

9952109

2-(((4-chloro-1-guanidino-7-isoquinolinyl)sulfonyl)amino)isobutyric acid;UK 371,804;UK 371804;UK-371,804;UK-371804;UK371,804;UK371804

DMSO : 8.33 mg/mL (21.59 mM; Need ultrasonic)

4

7

5

385.061 Da

385.061 Da

169.000 Ų

25

0

644.000

0

1

0.700