UKI-1

UKI-1

U656560-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

UKI-1 (WX-UK1) is a potent urokinase-type plasminogen activator (uPA) inhibitor with a K i of 0.41 μM. UKI-1 is also a low molecular weight serine protease inhibitor. UKI-1 is a potent antimetastatic agent and inhibits the invasive capacity of carcinoma cells In Vitro UKI-1 (WX-UK1; 0.1-1.0 μg/mL) treatment shows a decrease of tumor cell invasion by up to 50% is achieved in both models with the SCCHN line FaDu and the cervical carcinoma line HeLa. UKI-1 (WX-UK1) interferes with the plasminogen activation system at 2 levels: it inhibits plasmin formation directly and via inhibition of uPA. In vitro invasion models with highly invasive fibrosarcoma and breast cancer cells showed that UKI-1 effectively inhibits migration of the cells through fibrin matrices. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo UKI-1 (WX-UK1) treatment has antimetastatic activities that significantly reduces the number of metastatic lesions and tumor growth in metastasizing rat pancreatic and mammary adenocarcinoma tumor models . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Ki: 0.41 μM (Urokinase-type plasminogen activator (uPA)),Serine protease

UKI-1（WX-UK1）是一种强效的尿激酶型纤溶酶原激活剂（uPA）抑制剂，其 K i 为 0.41 μM。UKI-1 还是一种低分子量丝氨酸蛋白酶抑制剂。UKI-1 是一种有效的抗转移剂，可抑制癌细胞的侵袭能力。

220355-63-5(DMSO)

C32H47N5O5S

613.81 g/mol

CCOC(=O)N1CCN(CC1)C(=O)C(CC2=CC(=CC=C2)C(=N)N)NS(=O)(=O)C3=C(C=C(C=C3C(C)C)C(C)C)C(C)C