Information 2',3'-cGAMP Sodium Salt 2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium) is produced in response to DNA in the cytoplasm in mammalian cells and binds STING with high affinity and is an effective inducer of interferon-β (IFNβ) . 2',3'-cGAMP binds to STING with Kd of 3.79 nM. Targets STING (Cell-free assay) 3.79 nM(Kd) In vitro 2\',3\'-cGAMP is an endogenous second messenger produced by mammalian cells. 2\',3\'-cGAMP is a high affinity ligand for STING. 2\',3\'-cGAMP is a potent inducer of type-I interferons. 2\',3\'-cGAMP binding induces conformational changes of STING. Cell Research(from reference) Cell lines：A549, BSC-40, BSR-T7, Vero cells Concentrations：25 μM, 20 μM, 2.5 μM Incubation Time：30 min