西替利嗪甲基酯是羟嗪组胺H1受体拮抗剂的第二代修饰氧化代谢产物。作为第二代抗组胺药，它与H1受体的结合强度要比第一代抗组胺药强，并且据报道具有降低的脑渗透能力，并减少了与多巴胺，5-羟色胺，α-肾上腺素和钙通道受体的结合。 Cetirizine Methyl Ester is a second generation modified oxidative metabolite of hydroxyzine histamine H1 receptor antagonist. As a second generation anti-histamine it binds with greater strength to the H1 receptor than the first generation and has been documented to have reduced brain penetration along with decreased binding to dopamine, serotonin, α-adrenergic, and calcium channel receptors.