杀黑星菌素B 是一种抗生素，据报道是一种有效的ATP5（线粒体ATP合酶复合物）抑制剂。该化合物干扰位于膜上的K | + |和H | + | -ATPase通道的F | 0 |部分，并降低通道打开的可能性。通过阻止质子跨膜转移，杀黑星菌素B 导致ATP合酶活性停止。 Venturicidin B is an antibiotic that has been reported to be a potent inhibitor of the ATP5 (mitochondrial ATP synthase complex). This compound interferes with the F|0|portion of membrane-located K|+|and H|+|-ATPase channels and decreases probability of the channels from opening. By blocking proton transfer across the membrane, Venuricidin B causes a halt in ATP synthase activity.