Vafidemstat (ORY-2001) is an oral, brain penetrant, dual lysine-specific histone demethylase ( LSD1 )/ MAO-B inhibitor In Vitro Vafidemstat (ORY-2001), a dual LSD1/MAO-B inhibitor, is a novel epigenetic agent for the treatment of neurodegenerative diseases. LSD1 is a protein that participates in transcription regulation complexes; its modulation can be used to tweak transcriptional imbalances in neurodegenerative disease and redress neuroinflammation and cognitive deficit. Vafidemstat (ORY-2001) can be used in the treatment of Alzheimer's disease. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:LSD1/MAO-B