Application： (R)-(−)-Hexahydromandelic acid can be used: As an intermediate in the synthesis of antimycobacterial compound pyridomycin analogs. As a model α-hydroxy acid compound in the chirality sensing studies of organic probes using circular dichroism technique. As a starting material in the synthesis of chiral ionic liquids, which are applicable as chiral solvents in asymmetric synthesis and as chiral stationary phases in chromatographic separations.