Dalbavancin 是一种半合成糖肽，由A40926通过在天然糖肽先前未开发的区域中引入带正电的亲脂性部分而制得。这种修饰提供了更长的体外半衰期，并提高了其对多种革兰氏阳性和多药耐药菌株（例如MRSA和MRSE）的体外活性。 Dalbavancin is a semi-synthetic glycopeptide prepared from A40926 by introducing a positively charged lipophilic moiety in a previously unexplored region of the natural glycopeptide. This modification provides a longer in vitro half life, and improved in vitro activity against a variety of Gram positive and multi-drug resistant isolates such as MRSA and MRSE.