免疫球蛋白M,Fc5mu,人血浆

np001054-250μg

250μg

≥95%(SDS-PAGE)

IgM分子的FC部分对结构研究很重要，被认为会影响补体固定和胎盘通透性。 由经美国食品药品监督管理局要求的测试显示对HBsAg、抗-HCV、抗-HBc无反应且对抗-HIV 1和2呈阴性的血浆制备。 产品引用： Anquetil F等人。从类风湿性关节炎血清中纯化的IgM和IgA类风湿因子可增强疾病特异性抗瓜氨酸蛋白自身抗体的Fc受体和补体依赖性效应器功能。免疫学杂志。 2015 Apr 15;194(8):3664-74. doi: 10.4049/jimmunol.1402334. Epub 2015 Mar 13. Ref: Hayzer, D. J. et al. 1985. Methods Enzymol. 116, 26; Zikan, J. et al. 1973. Eur. J. Immunol. 3, 415; Plaut, A.G. et al. 1970. Proc. Natl. Acad. Sci. 65, 318. The FC portion of the IgM molecule is important for structural studies and is thought to influence complement fixation and placental permeability. Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests. Product Citation: Anquetil F, et al. IgM and IgA Rheumatoid Factors Purified from Rheumatoid Arthritis Sera Boost the Fc Receptor– and Complement-Dependent Effector Functions of the Disease-Specific Anti–Citrullinated Protein Autoantibodies. J Immunol. 2015 Apr 15;194(8):3664-74. doi: 10.4049/jimmunol.1402334. Epub 2015 Mar 13. Ref: Hayzer, D. J. et al. 1985. Methods Enzymol. 116, 26; Zikan, J. et al. 1973. Eur. J. Immunol. 3, 415; Plaut, A.G. et al. 1970. Proc. Natl. Acad. Sci. 65, 318.

342,000Da