GC-球蛋白,人血浆,混合型(维生素D结合蛋白)

np001096-250μg

250μg

≥95%(SDS-PAGE)

一种α2糖蛋白，由一条多肽链组成，在血浆中的含量为20-55mg/100ml。它在维生素D的结合和运输中起作用，也可能在肌动蛋白稳态中发挥重要作用，因为它已被证明能以高亲和力结合单体肌动蛋白。GC球蛋白还结合循环B和T淋巴细胞的膜。临床上，严重肝病患者的浓度会降低。GC球蛋白也可能在Itai-Itai病引起的骨软化症的机制中发挥重要作用。 An alpha 2 glycoprotein composed of a single polypeptide chain and present in plasma at levels of 20-55 mg/100 ml. It functions in the binding and transport of vitamin D and may also play an important role in actin homeostatis since it has been shown to bind monomeric actin with high affinity. GC-globulin also binds membranes of both circulating B and T lymphocytes. Clinically, concentrations are reduced in patients with severe liver diseases. GC-globulin may also play an important role in the mechanism of the osteomalacia that occurs with Itai-Itai disease. Product Citations: Trujillo, Glenda, David M. Habiel, Lingyin Ge, Mahalakshmi Ramadass, Nancy E. Cooke, and Richard R. Kew. "Neutrophil Recruitment to the Lung in Both C5a-and CXCL1-Induced Alveolitis Is Impaired in Vitamin D–Binding Protein-Deficient Mice." The Journal of Immunology (2013). Ge, Lingyin, Glenda Trujillo, Edmund J. Miller, and Richard R. Kew. "Circulating Complexes of the Vitamin D Binding Protein with G-Actin Induce Lung Inflammation by Targeting Endothelial Cells." Immunobiology (2013). Kilpatrick LE. Optimizing High Resolution Mass Spectrometry for the Identification of Low Abundance Post-Translational Modifications of Intact Proteins. J Proteome Res. 2017 Aug 8. doi: 10.1021/acs.jproteome.7b00244. [Epub ahead of print]. Ramadass M, Ghebrehiwet B, Kew RR. Enhanced recognition of plasma proteins in a non-native state by complement C3b. A possible clearance mechanism for damaged proteins in blood. Mol Immunol. 2015 Mar;64(1):55-62. doi: 10.1016/j.molimm.2014.10.022. Epub 2014 Nov 15. Ramadass M, Ghebrehiwet B, Smith RJ, Kew RR. Generation of Multiple Fluid-Phase C3b:Plasma Protein Complexes during Complement Activation: Possible Implications in C3 Glomerulopathies. J Immunol. 2014 Feb 1;192(3):1220-30. doi: 10.4049/jimmunol.1302288. Epub 2013 Dec 23.

56,000Da