细菌/渗透性增加蛋白，人中性粒细胞(BPI,CAP57)

np001122-25μg

25μg

≥95%(SDS-PAGE)

细菌/通透性增加蛋白（BPI）存在于多形核白细胞（PMN）的嗜天蓝色颗粒中。BPI仅对革兰氏阴性菌有毒。这种特异性归因于BPI对细菌包膜中脂多糖（LPS）的强烈吸引力。BPI也是血管炎中抗中性粒细胞胞浆自身抗体（ANCA）的重要抗原。 Bacterial/Permeability-Increasing Protein (BPI) is present in the azurophilic granules of polymorphonuclear leukocytes (PMN). BPI is toxic only toward Gram-negative bacteria. This specificity is attributable to the strong attraction of BPI for the lipopolysaccharides (LPS) in the bacterial envelope. BPI is also an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis. Product Citation: Zhao M.H., Jones S.J., and Lockwood C.M.. Clin Exp Immunol 1995. 99, 49. Elsbach P., and Weiss J. Immunobiology 1993. 187, 417. Budding, K., E. A. van de Graaf, T. Hoefnagel, C. E. Hack, and H. G. Otten. "Anti-BPIFA1/SPLUNC1: A new autoantibody prevalent in patients with endstage cystic fibrosis." Journal of Cystic Fibrosis (2013). Baron, Olga Lucia, Pieter van West, Benoit Industri, Michel Ponchet, Géraldine Dubreuil, Benjamin Gourbal, Jean-Marc Reichhart, and Christine Coustau. "Parental Transfer of the Antimicrobial Protein LBP/BPI Protects Biomphalaria glabrata Eggs against Oomycete Infections." PLoS Pathogens 9, no. 12 (2013): e1003792. Skopelja S, Hamilton BJ, Jones JD, Yang ML, Mamula M, Ashare A, Gifford AH, Rigby WF. The role for neutrophil extracellular traps in cystic fibrosis autoimmunity. JCI Insight. 2016 Oct 20;1(17):e88912.

55000