Recombinant Human Activin RIIB Protein

激活素A受体ⅡB(ACVR2B)重组蛋白

Activin receptor type IIB | ACTR-IIB | EC 2.7.11.30 | activin A receptor, type IIB | Activin receptor type IIB | activin receptor type-2B | Activin RIIB | ActivinRIIB | ACTRIIB | ActR-IIB | ACVR2B | EC 2.7.11 | EC 2.7.11.30 | MGC116908 | HTX4

rp142514-10μg

10μg

无动物源

≥95%(SDS-PAGE)

功能 与配体结合后，形成由两个 II 型和两个 I 型跨膜丝氨酸/苏氨酸激酶组成的受体复合物。II 型受体磷酸化并激活 I 型受体，I 型受体自动磷酸化，然后结合并激活 SMAD 转录调节因子。活化素 A、活化素 B 和抑制素 A 的受体。

Measured by its ability to inhibit Activin A-induced hemoglobin expression in K562 human chronic myelogenous leukemia cells. Approximately 0.3-1 µg/mL of rhActivin RIIB/Fc Chimera will inhibit 50% of the biological response due to 3 ng/mL of rhActivin A.

重组表达

14 kDa including tags

C-hFc & His

52 - 66 kDa, under reducing conditions; 100 - 130 kDa, under non-reducing conditions.

HEK293 Accession #: Q13705 | HEK293

<0.1 EU/μg

人(Human)

19-134 aa

SGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTENLYFQGMDPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH

Yes

Yes