Recombinant Human Angiopoietin-like 7/ANGPTL7 Protein

血管生成素样蛋白7(ANGPTL7)重组蛋白 | 重组人 ANGPTL7 蛋白

Angiopoietin like 7 | Angiopoietin like factor | Angiopoietin like factor (CDT6) | Angiopoietin related protein 7 | Angiopoietin-like factor | Angiopoietin-like protein 7 | Angiopoietin-related protein 7 | ANGL7_HUMAN | ANGPTL7 | AngX | CDT6 | Cornea deri

rp142833-10μg

10μg

无动物源

≥95%(SDS-PAGE)

≥95% (SDS-PAGE)

Purity ≥95% (SDS-PAGE) Endotoxin level ＜0.1 EU/μg Function Angiopoietin-like 7 (ANGPTL7), also known as Corneal-Derived Transcript 6 (CDT6), is a secreted glycoprotein that is structurally related to the angiopoietins. Members of this protein family contain an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain . ANGPTL7 shares 89% aa sequence identity with mouse and rat ANGPTL7. It is secreted as a 45 ‑ 50 kDa monomer that forms disulfide-linked homotrimers and tetramers via the coiled coil domain . ANGPTL7 is expressed in the corneal stroma, trabecular meshwork, and sclera and is elevated in glaucoma aqueous humor . Its production is up‑regulated in trabecular meshwork cells by glucocorticoids and TGF-beta and in cartilage by TNF-alpha. Overexpression of ANGPTL7 in trabecular meshwork cells inhibits the production of collagen and proteoglycans . When overexpressed in tumor cells it promotes collagen and proteoglycan deposition but inhibits tumor xenograft progression and tumor angiogenesis . Recently, ANGPTL proteins, including ANGPTL-2, -3, -4, -5 and -7, are identified as growth factors in combination with SCF, Thrombopoietin, IGF-II and FGF acidic that enhance the expansion and engraftment of human and mouse hematopoietic stem cells."

When Recombinant Human LILRB1/CD85j/ILT2 Protein (rp148284) is coated at 4.0 µg/mL, Biotinylated Recombinant Human Angiopoietin-like 7/ANGPTL7 Protein (rp142833) binds with the ED₅₀ of 2.0 μg/mL.

重组表达

36 kDa

C-His

34 - 35 kDa & 45 - 50 kDa , under reducing condition.

HEK293 Accession #: O43827 | HEK293

<0.1 EU/μg

人(Human)

27-346 aa

QKLSKHKTPAQPQLKAANCCEEVKELKAQVANLSSLLSELNKKQERDWVSVVMQVMELESNSKRMESRLTDAESKYSEMNNQIDIMQLQAAQTVTQTSADAIYDCSSLYQKNYRISGVYKLPPDDFLGSPELEVFCDMETSGGGWTIIQRRKSGLVSFYRDWKQYKQGFGSIRGDFWLGNEHIHRLSRQPTRLRVEMEDWEGNLRYAEYSHFVLGNELNSYRLFLGNYTGNVGNDALQYHNNTAFSTKDKDNDNCLDKCAQLRKGGYWYNCCTDSNLNGVYYRLGEHNKHLDGITWYGWHGSTYSLKRVEMKIRPEDFKPHHHHHH

Yes

Yes