Recombinant Human BMPR-IB/ALK-6 Protein

骨成型蛋白受体1B(BMPR1B)重组蛋白

BMP type-1B receptor | BMPR-1B | EC 2.7.11.30 | activin receptor-like kinase 6 | ALK-6 | ALK6CDw293 | BMP type-1B receptor | BMPR1B | BMPR-1B | BMPRIB | BMPR-IB | bone morphogenetic protein receptor type-1B | bone morphogenetic protein receptor, type IB |

rp143325-10μg

10μg

无动物源

≥90%(SDS-PAGE)

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5.

Measured by its ability to inhibit rhBMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 0.5‑1.5 µg/mL in the presence of 30 ng/mL of rhBMP-4.

重组表达

13.6 kDa

C-His

20-30 kDa, under reducing conditions

HEK293 Accession #: O00238 | HEK293

<0.1 EU/μg

人(Human)

14-126 aa

KKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHORRSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRHHHHHH

Yes

Yes